منابع مشابه
Ion-mediated conformational switches
Molecular switches are ubiquitous in Nature and provide the basis of many forms of transport and signalling. Single synthetic molecules that change conformation, and thus function, reversibly in a stimulus-dependent manner are of great interest not only to chemists but society in general; myriad applications exist in storage, display, sensing and medicine. Here we describe recent developments i...
متن کاملSubassembly Generation via Mechanical Conformational Switches
A question is posed on how a particular subassembly sequence is generated in randomized assembly. An extended design of mechanical conformational switches [16] is proposed that can encode several subassembly sequences. A particular subassembly sequence is generated due to conformational changes of parts during one-dimensional randomized assembly. The optimal subassembly sequence that maximizes ...
متن کاملProtein conformational switches: from nature to design.
Protein conformational switches alter their shape upon receiving an input signal, such as ligand binding, chemical modification, or change in environment. The apparent simplicity of this transformation--which can be carried out by a molecule as small as a thousand atoms or so--belies its critical importance to the life of the cell as well as its capacity for engineering by humans. In the realm ...
متن کاملAutomated Optimal Design of Mechanical Conformational Switches
Bacteriophage viruses spontaneously self-assemble in the presence of their component parts (certain protein molecules). It is believed that conformational switches, interacting chemical bonding sites that allow tentative incorrect bonds, facilitate this randomized assembly process. A onedimensional conformational switch is proposed and used to study the randomized assembly of mechanical parts. ...
متن کاملConformational switches modulate protein interactions in peptide antibiotic synthetases.
Protein dynamics plays an important role in protein function. Many functionally important motions occur on the microsecond and low millisecond time scale and can be characterized by nuclear magnetic resonance relaxation experiments. We describe the different states of a peptidyl carrier protein (PCP) that play a crucial role in its function as a peptide shuttle in the nonribosomal peptide synth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Science
سال: 2015
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c4sc03525a